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Anthrax was probably prevented by drugs given in response to the October 2001 attack on U.S. Sen. Tom Daschle's office, a study found.

Doctors at the Naval Medical Research Center in Silver Spring, Md., also found that more people were exposed to infection than predicted when a letter containing spores of Bacillus anthracis, the bacterium that causes the deadly disease, was opened in Daschle's office at the Hart Senate Office Building in Washington, D.C.

The study, led by Denise Doolan and Daniel Freilich, detected an immune response to the bacterium in people in or near the Daschle office as well as those elsewhere in the Hart building and even outside. The finding, published online in the Journal of Infectious Diseases, suggests people were exposed to traces of the pathogen over a wider area.

"The significance of low-level exposure should not be underestimated," the authors wrote.

Powdered anthrax sent to destinations including U.S. congressional offices and media outlets infected 22 people, killing five.

Anthrax most commonly occurs in wild and domestic animals including cattle, sheep, goats, camels and antelopes. It can occur in humans when they are exposed to infected animals or when anthrax spores are used as a weapon.

Those in or near Daschle's office judged likely to have been exposed received antibiotics or a vaccine, as did others within or outside the building, the Naval Medical Research Center doctors said.

The study was based on an analysis of symptoms and immune responses in 123 people out of more than 6,000 screened in the weeks after the attack, they said.